IGH/BCL2 t(14;18) by FISH

Test name:
FISH, IGH/BCL2 t(14;18)

Order name:
t(14;18) by FISH request

Specimen requirements:
Sodium heparin peripheral blood or bone marrow. Formalin fixed paraffin-embedded tissue (FFPE)

Minimum volume:
1mL blood or bone marrow. FFPE – 2 unstained 4µm thick sections on positively charged slides plus 1 stained H&E slide of the same block

Storage and stability information:
Room temperature 3 days for blood and bone marrow. FFPE at room temperature indefinitely.

Test performed:
Twice per week

Methodology:
Fluorescence in situ hybridization

Reference range:
See lab report

Clinical significance:
The t(14;18) translocation is found in 80 to 90% of follicular lymphomas, 30% of diffuse large B-cell lymphomas, and 15% of non-Hodgkin lymphomas.   

CPT codes:
88368 x 2