ALL Panel by FISH

Test name:
ALL panel by FISH (CEP 4/10/17, 11q23, t(9;22), t(12;21))

Order name:
ALL Panel by FISH request

Specimen requirements:
Sodium heparin peripheral blood or bone marrow

Minimum volume:
1 mL

Storage and stability information:
Room temperature 3 days

Test performed:
Twice per week

Methodology:
Fluorescence in situ hybridization

Reference range:
See lab report

Clinical significance:
Chromosome abnormalities are observed in up to 90% of acute lymphoblastic leukemia cases.  Abnormalities of both chromosome structure and chromosome number are observed. Hyperdiploidy in children with trisomies of chromosomes 4, 10 and 17 is associated with a good prognosis when structural anomalies are absent. The t(12;21) translocation also has a good prognosis and is a subtle abnormality best detected by FISH.  Abnormalities of 11q23 and the t(9;22) translocation are associated with a poor prognosis.

CPT codes:
88368 x 9